Research Articles

Due to differences in animal/human physiology the findings of in vivo studies cannot be translated to effects on human health. In vitro studies on cell cultures also do not guarantee results in humans.

Findings may be an indicator of potential results in humans. Clinical trials are needed to verify extrapolations from laboratory tests.

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Category	Component	Body System	Type	Title
Cancer	Bicyclogermacrene,Spathulenol	N/A	In Vitro	Chemical Profile and in vitro Biological Activities of Essential Oils of Nectandra puberula and N. cuspidata from the Amazon
Covid-19	Bicyclogermacrene,β-caryophyllene	Lung	In Silico	Recognition of Natural Products as Potential Inhibitors of COVID‑19 Main Protease (Mpro): In‑Silico Evidences
Antifungal	Bicyclogermacrene	N/A	In Vitro	Biciclogermacreno, resveratrol e atividade antifúngica em extratos de folhas de Cissus verticillata (L.) Nicolson & Jarvis (Vitaceae)
Antiparasitic	Bicyclogermacrene	N/A	In Vitro	Chemical composition and in vitro cytotoxic and antileishmanial activities of extract and essential oil from leaves of Piper cernuum
Antiparasitic	Bicyclogermacrene	N/A	In Vitro	In Vitro antileishmania activity of sesquiterpene-rich essential oils from Nectandra species
Antibacterial,Anti-oxidant	Bicyclogermacrene	N/A	In Vivo	Chemical Composition and Antioxidant, Antimicrobial, and Larvicidal Activities of the Essential Oils of Annona salzmannii and A. pickelii (Annonaceae)
Cancer	Bicyclogermacrene	Skin,Brain,Reproductive,Colon,Breast	In Vitro	Chemical composition and in vitro cytotoxic effects of the essential oil from Nectandra leucantha leaves
Antifungal	Bicyclogermacrene,Spathulenol	Skin,Mouth	In Vitro,In Vivo	Antifungal activity of essential oils of Croton species from the Brazilian Caatinga biome
Antibacterial	Alpha-Muurolol	N/A	In Vivo	Cytotoxic Effect and TLC Bioautography-Guided Approach to Detect Health Properties of Amazonian Hedyosmum sprucei Essential Oil
Antibacterial	Alpha-Muurolol	N/A	In Vitro	Chemical Composition, Antifungal and Antioxidant Activities of Hedyosmum brasiliense Mart. ex Miq. (Chloranthaceae) Essential Oils
Muscle Relaxant	T-Cadinol	All	In Vitro	T-cadinol: a pharmacologically active constituent of scented myrrh: introductory pharmacological characterization and high field 1H- and 13C-NMR data
Protectant,Inflammation	Nerolidol	Heart	In Vivo	Nerolidol improves cardiac function in spontaneously hypertensive rats by inhibiting cardiac inflammation and remodelling associated TLR4/ NF-κB signalling cascade
Toxicity,Protectant,Anti-oxidant	Related pharmacology	Spleen	In Vivo	MiR-182–5p/TLR4/NF-κB axis contributes to the protective effect of caffeic acid phenethyl ester against cadmium-induced spleen toxicity and associated damage in mice
Disease	Related pharmacology	All	In Silico	Pharmacological modulation of redox signaling pathways in disease
Cancer	Related pharmacology	N/A	In Vitro	Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming